References
I. T cell adoptive immunity for cancer
Beatty GL, Haas AR, Maus MV, Torigian DA, Soulen MC, Zhao Y, Levine BL, Albelda SM, Kalos M, June CH: Mesothelin-specific Chimeric Antigen Receptor mRNA-Engineered T cells Induce Anti-Tumor Activity in Solid Malignancies. Cancer Immunology Research 2(2):1-9, December 2013 Notes: DOI: 10.1158/2326-6066.CIR-13-0170. Grupp SA, Kalos M, Barrett D, Aplenc R, Porter DL, Rheingold SR, Teachey DT, Chew A, Hauck B, Wright JF, Milone MC, Levine BL, June CH: Chimeric Antigen Receptor-Modified T Cells for Acute Lymphoid Leukemia. New England Journal of Medicine 368(16):1509-18, April 2013 Notes: doi: 10.1056/NEJMoa1215134. Epub 2013 Mar 25. PMCID: 23527958 Fowler DH, Mossoba ME, Steinberg SM, Halverson DC, Stroncek D, Khuu HM, Hakim FT, Castiello L, Sabatino M, Leitman SF, Mariotti J, Gea-Banacloche JC, Sportes C, Hardy NM, Hickstein DD, Pavletic SZ, Rowley S, Goy A, Donato M, Korngold R, Pecora A, Levine BL, June CH, Gress RE, Bishop MR: Phase II clinical trial of rapamycin-resistant donor CD4+ Th2/Th1 (T-Rapa) cells after low-intensity allogeneic hematopoietic cell transplantation. Blood February 2013 Notes: ePub ahead of print, doi: 10.1182/blood-2012-08-446872. PMCID: 23426943 Grupp SA, Luning Prak E, Boyer J, McDonald KR, Shusterman S, Thompson E, Callahan C, Jawad A, Levine BL, June CH, Sullivan KE: Adoptive Transfer of Autologous T cells Improves T Cell Repertoire Diversity and Long Term B cell Function in Pediatric Patients with Neuroblastoma. Clinical Cancer Research 18(24): 6732-41, December 15 2012 Notes: doi: 10.1158/1078-0432.CCR-12-1432. Epub 2012 Oct 23. PMCID: 23092876 Hardy NM, Mossoba ME, Steinberg SM, Fellowes V, Yan XY, Hakim FT, Babb RR, Avila D, Gea-Banacloche J, Sportès C, Levine BL, June CH, Khuu HM, Carpenter AE, Krumlauf MC, Dwyer AJ, Gress RE, Fowler DH, Bishop MR: Phase I Trial of Adoptive Cell Transfer with Mixed-Profile Type-I/Type-II Allogeneic T Cells for Metastatic Breast Cancer. Clinical Cancer Research 17(21): 6878, November 2011 Notes: Epub 2011 Sep 26. PMCID: 21948234 *Kalos M, *Levine BL, Porter DL, Katz S, Grupp SA, Bagg A, June CH: T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Science Translational Medicine 3(95): 95ra73, August 2011 Notes: *Equal contribution. PMCID: 21832238 Porter DL, Levine BL, Kalos M, Bagg A, June CH: Chimeric Antigen Receptor-Modified T Cells in Chronic Lymphoid Leukemia. New England Journal of Medicine 365(8): 725-33, August 2011 Notes: Epub 2011 Aug 10, accompanying Editorial "Redirecting T Cells" Urba WJ, Longo DL, PMID 21830939 PMCID: 21830940 Rapoport AP, Aqui NA, Stadtmauer EA, Vogl DT, Fang HB, Cai L, Janofsky S, Chew A, Storek J, Akpek G, Badros A, Yanovich S, Tan MT, Veloso E, Pasetti MF, Cross A, Philip S, Murphy H, Bhagat R, Zheng Z, Milliron T, Cotte J, Cannon A, Levine BL, Vonderheide RH, June CH: Combination immunotherapy using adoptive T-cell transfer and tumor antigen vaccination based on hTERT and survivin following ASCT for myeloma. Blood 117(3): 788-797, January 2011 Notes: Epub ahead of print,doi:10.1182/blood-2010-08-299396 PMCID: 21030558 Zhao Y, Moon E, Carpenito C, Paulos CM, Liu X, Brennan AL, Chew A, Carroll RG, Scholler J, Levine BL, Albelda SM, June CH: Multiple injections of electroporated autologous T cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor Cancer Research 70(22): 9053, November 2010 Notes: Epub 2010 Oct 5 doi: 10.1158/0008-5472.CAN-10-2880. PMCID: PMID: 20926399 Zhao Y, Moon E, Carpenito C, Paulos CM, Liu X, Brennan AL, Chew A, Carroll RG, Scholler J, Levine BL, Albelda SM, June CH: Multiple injections of electroporated autologous T cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor Cancer Research 70(22): 9053, November 2010 Notes: Epub 2010 Oct 5 doi: 10.1158/0008-5472.CAN-10-2880. PMCID: PMID: 20926399 Powell DJ Jr, Brennan AL, Zheng Z, Huynh H, Cotte J, Levine BL, Efficient Clinical-Scale enrichment of Lymhocytes for Use in Adoptive Immunotherapy Using a Modified Counterflow Centrifugal Elutriation Program. Cytotherapy. 2009;25:1-13. Tammana S, Huang X, Wong M, Milone M, Ma L, Levine BL, June CH, Wagner JE, Blazar BR, Zhou X. 4-1BB and CD28 Signaling Plays A Synergistic Role in Redirecting Umbilical Cord Blood T Cells against B-Cell Malignancies Human Gene Therapy. doi:10.1089/hum.2009.122. Zhou Q, Bucher C, Munger ME, Highfill SL, Tolar J, Munn DH, Levine BL, Riddle M, June CH, Vallera DA, Weigel BJ, Blazar BR. Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T cell immunotherapy in murine acute myeloid leukemia. Blood. 2009;3-208181v1. Rapoport A, Stadtmauer E, Aqui N, Vogl D, Chew A, Fang H, Yager K, Janofsky S, Veloso E, Zheng Z, Milliron T, Westphal S, Cotte J, Huynh H, Cannon A, Yanovich S, Akpek G, Tan M, Virts K, Ruehle K, Harris C, Philip S, Vonderheide R, Levine BL, June C. Rapid Immune Recovery and GVHD-like Engraftment Syndrome Following Adoptive Transfer of Costimulated Autologous T Cells. American Association for Cancer Research.2009;13:4499-507. Penn Medicine Clinical Briefing (2008) - Restoration of immunity in lymphopenic patients with cancer via immunotherapy with vaccination and adoptive T cell transfer of vaccine-primed activated autologous T cells. Porter DL, Levine BL, Bunin N, Stadtmauer EA, Luger SM, Goldstein S, Loren A, Phillips J, Nasta S, Perl A, Schuster S, Tsai D, Sohal A, Veloso E, Emerson S, June CH. A phase 1 trial of donor lymphocyte infusions expanded and activated ex vivo via CD3/CD28 costimulation. Blood. 2006;107:1325-1331. Fowler DH, Odom J, Steinberg SM, Chow CK, Foley J, Kogan Y, Hou J, Gea-Banacloche J, Sportes C, Pavletic S, Leitman S, Read EJ, Carter C, Kolstad A, Fox R, Beatty GL, Vonderheide RH, Levine BL, June CH, Gress RE, Bishop MR. Phase I Clinical Trial of Costimulated, IL-4 Polarized Donor CD4_ T Cells as Augmentation of Allogeneic Hematopoietic Cell Transplantation. Biology of Blood and Marrow Transplantation. 2006; 12: 1150-1160. Rapoport AP, Stadtmauer EA, Aqui N, Badros A, Cotte J, Chrisley L, Veloso E, Zheng Z, Westphal S, Mair R, Chi N, Ratterree B, Pochran MF, Natt S, Hinkle J, Sickles C, Sohal A, Ruehle K, Lynch C, Zhang L, Porter DL, Luger S, Guo C, Fang HB, Backwelder W, Hankey K, Mann D, Edelman R, Frasch C, Levine BL, Cross A, June CH. Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer. Nature Medicine. 2005;11(11):1230-1237. Rapoport, AP, Levine BL, Badros A, Meisenberg B, Ruehle K, Nandi A, Rollins S, Natt S, Ratterree B, Westphal S, Mann D, and June CH. 2004. Molecular remission of CML after autotransplantation followed by adoptive transfer of costimulated autologous T cells. Bone Marrow Transplant. 33:53-60. II. Gene-modified T cells for HIV Tebas, P, Stein, D, Tang, WW, Frank, I, Wang, SQ, Lee, G, Spratt, SK, Surosky, RT, Giedlin, MA, Nichol, G, Holmes, MC, Gregory, PD, Ando, DA, Kalos, M, Collman, RG, Binder-Scholl, G, Plesa, G, Hwang, W-T, Levine, BL, June, CH: Gene Editing of CCR5 in Autologous CD4 T-cells of Persons Infected with HIV. New England Journal of Medicine 2014 Notes: In Press. Wang GP, Levine BL, Binder GK, Berry CC, Malani N, McGarrity G, Tebas P, June CH, Bushman FD. Analysis of Lentiviral Vector Integration in HIV+ Study Subjects Receiving Autologous Infusions of Gene Modified CD4+ T Cells. The American Society of Gene Therapy. 2009;10:1-7. Yu JJ, Wu TL, Liszewski MK, Dai J, Swiggard WJ, Baytop C, Frank I, Levine BL, Yang W, Theodosopoulos T, O'Doherty U: A more precise HIV integration assay designed to detect small differences finds lower levels of integrated DNA in HAART treated patients. Virology 82(10): 78-86, September 2008. PMCID: PMID: 18649912 Levine BL, Humeau LM, Boyer J, MacGregor RR, Rebello T, Lu X, Binder GK, Slepushkin V, Lemiale F, Mascola JR, Bushman FD, Dropulic B, June CH. Gene transfer in humans using a conditionally replicating lentiviral vector. PNAS. 2006;103(46):17372-17377. Manilla P, Rebello T, Afable C, Lu X, Slepushkin V, Humeau LM, Schonely K, Ni Y, Binder GK, Levine BL, Macgregor RR, June CH, Dropulic B. Regulatory Considerations for Novel Gene Therapy Products: A Review of the Process Leading to the First Clinical Lentiviral Vector. Human Gene Therapy. 2005;16:17-25. Review. PDF. Bernstein WB, Cox JH, Aronson NE, Tracy L, Schlienger K, Ratto-Kim S, Garner R, Cotte J, Zheng Z, Wineston L, Liebig C, Galley LM, Connor M, Birx DL, Carroll RG, Levine BL. Immune reconstitution following autologous transfers of CD3/CD28 stimulated CD4+ T cells to HIV-infected persons. Clinical Immunology. 2004;111:262-274. Humeau LM, Binder GK, Lu X, Slepushkin V, Merling R, Echeagaray P, Pereira M, Slepushkina T, Barnett S, Dropulic LK, Carroll R, Levine BL, June CH, Dropulic B. Efficient Lentiviral Vector-Mediated Control of HIV-1 Replication in CD4 Lymphocytes from Diverse HIV+ Infected Patients Grouped According to CD4 Count and Viral Load. Molecular Therapy. 2004; 9(6):902-913. Levine BL, Bernstein WB, Aronson NE, Schlienger K, Cotte J, Peretto S, Humphries MJ, Ratio-Kim S, Birx DL, Steffens C, Landay A, Carroll RG, June CH. Adoptive transfer of costimulated CD4+ T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection. Nature Medicine. 2002; 8:47-53. III. Dendritic cell vaccines for cancer Chiang CL, Kandalaft L, Tanyi JL, Hagemann AR, Motz GT, Svoronos N, Montone K, Mantia-Smaldone GM, Nisenbaum HL, Levine BL, Kalos M, Czerniecki BJ, Torigian DA, Powell DJ Jr, Mick R, Smith L, Coukos G: A Dendritic Cell Vaccine Pulsed with Autologous Hypochlorous Acid-Oxidized Ovarian Cancer Lysate Primes Effective Broad Antitumor Immunity: From Bench to Bedside. Clinical Cancer Research July 2013 Notes: Published OnlineFirst on July 9, 2013; DOI: 10.1158/1078-0432.CCR-13-118. PMCID: 23838316 Kandalaft, LE, Powell Jr., DJ, Chiang, CL, Tanyi, J, Kim, S, Bosch, M, Montone, K, Mick, R, Torigian, DA, Levine, BL, June, CH, Coukos, G: Autologous Lysate-pulsed Dendritic Cell Vaccination Followed by Adoptive Transfer of Vaccine-primed Ex Vivo Costimulated T-cells in Recurrent Ovarian Cancer Oncoimmunology 2(1): 1-9, January 2013 Notes: eLocation ID: e22664. PMCID: 23482679 Sharma A, Koldovsky U, Xu S, Mick R, Roses R, Fitzpatrick E, Weinstein S, Nisenbaum H, Levine BL, Fox K, Zhang P, Koski G, Czerniecki BJ: HER-2 pulsed dendritic cell vaccine can eliminate HER-2 expression and impact ductal carcinoma in situ. Cancer January 2012 Notes: doi: 10.1002/cncr.26734. [Epub ahead of print] PMCID: 22252842 Koski GK, Koldovsky U, Xu S, Mick R, Sharma A, Weinstein S, Nisenbaum H, Levine BL, Fox K, Zhang P, Czerniecki BJ: A novel dendritic cell-based immunization approach for the induction of durable Th1-polarized anti-HER-2/neu responses in women with early breast cancer. Journal of Immunotherapy 35(1): 54, January 2012 Notes: Epub ahead of print November, 2011. PMCID: 22130160 Chu CS, Boyer J, Schullery DS, Gimotty PA, Gamerman V, Bender J, Levine BL, Coukos G, Rubin SC, Morgan MA, Vonderheide RH, June CH: Phase I/II randomized trial of dendritic cell vaccination with or without cyclophosphamide for consolidation therapy of advanced ovarian cancer in first or second remission. Cancer Immunology and Immunotherapy October 2011 Notes: Epub ahead of print, DOI 10.1007/s00262-011-1081-8. PMCID: 22021066 Czerniecki BJ, Koski GK, Kolodovsky U, Xu Sh, Cohen PA, Mick R, Niesenabum H, Pasha T, Xu M, Fox KR, Weinstein S, Orel SG, Vonderheide R, Coukos G, DeMichele A, Araujo L, Spitz FR, Rosen M, Levine BL, June C, Zhang PJ. Targeting HER-2/neu in Early Breast Cancer Development Using Dendritic Cells with Staged Interleukin-12 Burst Secretion. Cancer Research. 2007; 67 (4):1842-1852. IV. Reviews© The Trustees of the University of Pennsylvania | 3400 Spruce Street Philadelphia, PA 19104